Lomeguatrib, MGMT inhibitor (ab142741)
Key features and details
- Potent MGMT inhibitor
- CAS Number: 192441-08-0
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Lomeguatrib, MGMT inhibitor -
Description
Potent MGMT inhibitor -
Biological description
Potent O6-methylguanine-DNA methyltransferase (MGMT) inhibitor (IC50 = 9 nM). Inhibits recombinant human ATase (IC50 = 5 nM). Shows antitumor effects in vivo. Enhances antitumor effects of temozolomide (ab141055).
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Purity
> 98% -
General notes
Sold under license from CRT -
CAS Number
192441-08-0 -
Chemical structure
Properties
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Chemical name
6-[(4-Bromothiophen-2-yl)methoxy]-7H-purin-2-amine -
Molecular weight
326.17 -
Molecular formula
C10H8BrN5OS -
PubChem identifier
3025944 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N -
Source
Synthetic
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Research areas
