LM22A-4, neurotrophic BDNF mimetic (ab222020)
Key features and details
- Neurotrophic BDNF mimetic; Partial TrkB agonist.
- CAS Number: 37988-18-4
- Purity: > 98%
- Soluble in water to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LM22A-4, neurotrophic BDNF mimetic -
Description
Neurotrophic BDNF mimetic; Partial TrkB agonist. -
Biological description
Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC50 = 47 nM) in binding assays. Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of neurodegenerative disease. Causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats, after in vivo administraton. Improves respiratory function in a mouse model of Rett syndrome.
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Purity
> 98% -
CAS Number
37988-18-4 -
Chemical structure
Properties
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Chemical name
N,N',N''-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide -
Molecular weight
339.35 -
Molecular formula
C15H21N3O6 -
PubChem identifier
2054170 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in water to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO -
Source
Synthetic
