Lipid peroxidation refers to the oxidative degradation of lipids. In this process free radicals take electrons from the lipids (generally in cell membranes), resulting in cell damage. Quantification of lipid peroxidation is essential to assess oxidative stress. Lipid peroxidation forms reactive aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4- HNE) as natural bi-products. Malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) are often used as markers of lipid peroxidation, and to assay for oxidative damage / oxidative stress.

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Review the oxidative stress marker and assay guide, or the full metabolism assay guide to learn about more assays for metabolites, metabolic enzymes, mitochondrial function, and oxidative stress, and also how to assay metabolic function in live cells using your plate reader.

Also see the popular 4-HNE Assay Kit ab238538 as an alternative marker of lipid peroxidation and oxidative stress.

How other researchers have used Lipid Peroxidation Assay Kit ab118970

The MDA/TBARs assay kit has been used in publications in a variety of sample types, including:
- Human: serum¹, hippocampal primary cell extracts², A375 cultured cell lysates³, plasma and platelet samples⁴
- Mouse: neuronal cell lysates⁵, heart tissue extract⁶, plasma⁷, cell extracts⁸
- Rat: hippocampal tissue extracts⁹, cardiomyocyte extracts of cultured cells¹⁰, lung lysates¹¹
- Pig: serum¹²

^{References: 1 - Shen J et al. 2018, 2 - Wang Q et al. 2019, 3 - Luo M et al. 2018,  4 - Mustafa AG et al. 2018, 5 - Murphy K et al. 2018, 6 - Guan F et al. 2019, 7 - Costa CRC et al. 2018, 8 - Eleftheriadis T et al. 2019, 9 - Malekiyan et al. 2019, 10 - Zhou Z et al. 2018, 11 - Li L et al. 2018, 12 - Lee SE and Kang KS 2019}