Linsitinib (OSI-906) (ab273391)
Key features and details
- Potent and selective dual IGF-1R and Insulin Receptor kinase inhibitor
- CAS Number: 867160-71-2
- Purity: = 98%
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Linsitinib (OSI-906) -
Description
Potent and selective dual IGF-1R and Insulin Receptor kinase inhibitor -
Biological description
Potent and selective dual IGF-1R (IC50 = 35 nM in cell-free assay) and Insulin Receptor (IC50 = 75 nM in cell-free assay) kinase inhibitor. Inactive towards Abl, ALK, BTK, EGFR, FGFR1/2 and PKA. Displayed
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Purity
= 98% -
CAS Number
867160-71-2 -
Chemical structure
Properties
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Chemical name
cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol
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Molecular weight
421.51 -
Molecular formula
C26H23N5O -
PubChem identifier
11640390 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 50 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Linsitinib (OSI-906) (ab273391)
Chemical structure of Linsitinib (OSI-906), 867160-71-2