Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor
CAS Number: 111358-88-4
Purity: > 98%
Soluble in DMSO to 10 mM
Form / State: Solid
Source: Synthetic

Product name

Lestaurtinib, JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor
Description

Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor
Biological description

Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor (IC₅₀ values are 0.9, 3 and 25 nM respectively). Antiproliferative effects in vitro. Antileukemic agent in vivo. Orally active.
Purity

> 98%
CAS Number

111358-88-4
Chemical structure

Chemical name

(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
Molecular weight

439.46
Molecular formula

C₂₆H₂₁N₃O₄
PubChem identifier

126565
Storage instructions

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overview

Soluble in DMSO to 10 mM
Handling

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
SMILES

CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Source

Synthetic
Research areas
- Biochemicals
- Pharmacology
- Enzymes
- Kinase
- JAK
- Inhibitors

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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Astana Biomed Group, an authorized Abcam distributor in Central Asia

Lestaurtinib, JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor (ab142107)

Key features and details

Overview

Product name

Description

Biological description

Purity

CAS Number

Chemical structure

Properties

Chemical name

Molecular weight

Molecular formula

PubChem identifier

Storage instructions

Solubility overview

Handling

SMILES

Source

Research areas

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