LCL161 (ab273616)
Key features and details
- Potent IAP inhibitor
- CAS Number: 1005342-46-0
- Purity: > 99%
Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
LCL161 -
Description
Potent IAP inhibitor -
Biological description
Small molecule SMAC mimetic inhibitor of multiple IAP (Inhibitor of apoptosis) family proteins. (IC50 = 10.23 μM). Inhibits cell proliferation and viability in two human hepatocellular carcinoma cells (Hep3B, IC50 = 10, and PLC5, IC50 = 19).
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Purity
> 99% -
General notes
For obtaining a higher solubility, please warm the tube at 37°C and shake in the ultrasonic bath for a while.
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CAS Number
1005342-46-0 -
Chemical structure
Properties
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Chemical name
(2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-(4-fluorobenzoyl)-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)-propanamide
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Molecular weight
500.63 -
Molecular formula
C26H33FN4O3S -
PubChem identifier
24737642 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM
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Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC -
Source
Synthetic
Images
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Chemical Structure - LCL161 (ab273616)
Chemical structure of LCL161, 1005342-46-0