L779450, Raf kinase inhibitor (ab120837)
Key features and details
- Potent Raf kinase inhibitor
- CAS Number: 303727-31-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
L779450, Raf kinase inhibitor -
Description
Potent Raf kinase inhibitor -
Biological description
Potent Raf kinase inhibitor (IC50 = 10 nM). Inhibits Raf-1 activation. Competes for ATP at the protein kinase catalytic site. Supresses DNA synthesis and induces apoptosis. Additionally inhibits p38.
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Purity
> 98% -
CAS Number
303727-31-3 -
Chemical structure
Properties
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Chemical name
2-Chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]phenol -
Molecular weight
347.80 -
Molecular formula
C20H14ClN3O -
PubChem identifier
9950176 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1ccc(cc1O)c2nc(nc2c3ccncc3)c4ccccc4 -
Source
Synthetic
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Research areas
