KRIBB11, heat shock factor inhibitor (ab254320)
Key features and details
- Heat shock factor 1 (HSF1) inhibitor
- CAS Number: 342639-96-7
- Purity: > 98%
Soluble in DMSO to >75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KRIBB11, heat shock factor inhibitor -
Description
Heat shock factor 1 (HSF1) inhibitor -
Biological description
Heat shock factor 1 (HSF1) inhibitor (IC50 = 1.2 μM). Down-regulates HSP70 and HSP27 expression. Inhibits cancer cell proliferation. Promotes cell cycle arrest at G2/M phase. Induces apoptosis. Does not inhibit heat shock-induced HSF1 recruitment to HSP70 promotor. Does not inhibit HSF1 phosphorylation at Ser 230. Inhibits tumor growth in mouse xenograft models. Promotes Mcl-1 degradation via and HSF1-independent pathway.
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Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
342639-96-7 -
Chemical structure
Properties
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Chemical name
2-N-(1H-Indazol-5-yl)-6-N-methyl-3-nitropyridine-2,6-diamine
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Molecular weight
284.28 -
Molecular formula
C13H12N6O2 -
PubChem identifier
69894253 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to >75 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CNC1=NC(=C(C=C1)[N+](=O)[O-])NC2=CC3=C(C=C2)NN=C3 -
Source
Synthetic
