KD5170, HDAC inhibitor (ab144557)
Key features and details
- Potent, non-selective HDAC inhibitor. Antiproliferative agent.
- CAS Number: 940943-37-3
- Purity: > 96%
- Soluble in DMSO to 100 mM and in 1eq. HCl to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KD5170, HDAC inhibitor -
Description
Potent, non-selective HDAC inhibitor. Antiproliferative agent. -
Biological description
Potent, non-selective HDAC inhibitor (IC50 values are 14, 20, 26 and 75 nM for HDAC6, 1, 4, and 3, respectively and 2 μM for HDAC2). Antiproliferative agent. Induces oxidative stress and oxidative DNA damage. Shows antitumor effects in vivo. Orally active.
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Purity
> 96% -
CAS Number
940943-37-3 -
Chemical structure
Properties
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Chemical name
S-[2-[6-[[4-[3-(Dimethylamino)propoxy]phenyl]sulfonylamino]-3-pyridinyl]-2-oxoethyl] ethanethioic acid ester -
Molecular weight
451.55 -
Molecular formula
C20H25N3O5S2 -
PubChem identifier
17754557 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in 1eq. HCl to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=O)SCC(=O)C1=CN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)OCCCN(C)C -
Source
Synthetic
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Research areas
