KB-R7943, NCX inhibitor (ab120284)
Key features and details
- NCX inhibitor. TRPC blocker.
- CAS Number: 182004-65-5
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
KB-R7943, NCX inhibitor -
Description
NCX inhibitor. TRPC blocker. -
Biological description
Potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = ~0.32 μM in guinea pig ventricular cells). Also potent blocker of TRPC channels (IC50 values are 0.46, 0.71 and 1.38 μM at TRPC3, TRPC6 and TRPC5, respectively).
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Purity
> 98% -
CAS Number
182004-65-5 -
Chemical structure
Properties
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Chemical name
2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester carbamimidothioic acid methanesulfonate -
Molecular weight
427.49 -
Molecular formula
C16H17N3O3S.CH3SO3H -
PubChem identifier
9823846 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CS(=O)(=O)O.[O-][N+](=O)c2ccc(COc1ccc(cc1)CCSC(=N)N)cc2 -
Source
Synthetic
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Research areas