JNJ-7777120, histamine H4 receptor antagonist (ab144405)
Key features and details
- Potent, highly selective histamine H4 receptor antagonist
- CAS Number: 459168-41-3
- Purity: > 98%
- Soluble in DMSO to 50 mM and in 1 eq. HCl to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
JNJ-7777120, histamine H4 receptor antagonist -
Description
Potent, highly selective histamine H4 receptor antagonist -
Biological description
Potent, highly selective histamine H4 receptor antagonist (Ki = 4.5 nM). Shows anti-inflammatory, antifibrotic and antiallergic effects in vivo. -
Purity
> 98% -
CAS Number
459168-41-3 -
Chemical structure
Properties
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Chemical name
(5-Chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)methanone -
Molecular weight
277.75 -
Molecular formula
C14H16ClN3O -
PubChem identifier
4908365 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 50 mM and in 1 eq. HCl to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)Cl -
Source
Synthetic
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Research areas
