JNJ-10198409, PDGF-BB tyrosine kinase inhibitor (ab144450)
Key features and details
- Potent ATP-competitive PDGF-BB tyrosine kinase inhibitor. Antiangiogenic agent.
- CAS Number: 627512-69-0
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 75 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
JNJ-10198409, PDGF-BB tyrosine kinase inhibitor -
Description
Potent ATP-competitive PDGF-BB tyrosine kinase inhibitor. Antiangiogenic agent. -
Biological description
Potent ATP-competitive PDGF-BB tyrosine kinase inhibitor (IC50 = 4.2 nM). Antiangiogenic agent. Inhibits TGF-β1-mediated elongation and stiffening response. Selectively blocks Actn1 activation. Shows antiproliferative and antitumor effects in vivo. Orally active. -
Purity
> 98% -
CAS Number
627512-69-0 -
Chemical structure
Properties
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Chemical name
N-(3-Fluorophenyl)-2,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine -
Molecular weight
325.34 -
Molecular formula
C18H16FN3O2 -
PubChem identifier
9797370 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 75 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC1=C(C=C2C(=C1)CC3=C2NN=C3NC4=CC(=CC=C4)F)OC -
Source
Synthetic
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Research areas