Istradefylline (KW-6002) (ab270806)
Key features and details
- Competitive inhibitor of adenosine A2A receptors
- CAS Number: 155270-99-8
- Purity: >= 99%
Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Istradefylline (KW-6002) -
Description
Competitive inhibitor of adenosine A2A receptors -
Biological description
Competitive inhibitor of adenosine A2A receptors. Selective for the adenosine A2A receptor (Ki = 2.2 nM) versus the adenosine A1 receptor (Ki = 150 nM). Increases dopamine levels in normal animals and Parkinson's disease animal models. Improves cognitive performance in animal models. Anti-cataleptic activity. Decreases GABA release. Elicits conditioned place preference response.
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Purity
>= 99% -
CAS Number
155270-99-8 -
Chemical structure
Properties
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Chemical name
8-[(1E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
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Molecular weight
384.43 -
Molecular formula
C20H24N4O4 -
PubChem identifier
5311037 -
Storage instructions
Shipped at Room Temperature. Store at Room Temperature. -
Solubility overview
Soluble in DMSO to 10 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C -
Source
Synthetic
Images
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Chemical Structure - Istradefylline (KW-6002) (ab270806)
Chemical structure of Istradefylline (KW-6002), 155270-99-8
