Isobavachalcone, Akt inhibitor (ab141168)
Key features and details
- Akt inhibitor. Natural chalcone.
- CAS Number: 20784-50-3
- Purity: > 99%
- Soluble in DMSO to 100 mM and ethanol to 100 mM
- Form / State: Solid
- Source: Psoralea corylifolia
Overview
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Product name
Isobavachalcone, Akt inhibitor -
Description
Akt inhibitor. Natural chalcone. -
Biological description
Inhibits Akt activation and subsequent downstream signaling to evoke apoptosis. Constituent of P. longum. Displays antiproliferative and antioxidant activity. Active in vivo. -
Purity
> 99% -
CAS Number
20784-50-3 -
Chemical structure
Properties
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Chemical name
(2E)-1-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one -
Molecular weight
324.38 -
Molecular formula
C20H20O4 -
PubChem identifier
5281255 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and ethanol to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Oc1c(ccc(O)c1C\C=C(/C)C)C(=O)/C=C/c2ccc(O)cc2 -
Source
Psoralea corylifolia
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Research areas
Images
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Functional Studies - Isobavachalcone, Akt inhibitor (ab141168)ab7977 staining Bax in SK-N-SH cells treated with isobavachalcone (ab141168), by ICC/IF. Increase of Bax expression correlates with increased concentration of isobavachalcone, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab141168 (isobavachalcone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.