IOX2, HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor (ab218604)
Key features and details
- Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
- CAS Number: 931398-72-0
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IOX2, HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor -
Description
Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor -
Alternative names
- JICL38
- N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine
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Biological description
Potent, cell-permeable, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor (IC50 = 21 nM). Displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases JMJD2A, JMJD2C, JMJD2E and JMJD3.
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Purity
> 98% -
CAS Number
931398-72-0 -
Chemical structure
Properties
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Chemical name
N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine -
Molecular weight
352.34 -
Molecular formula
C19H16N2O5 -
PubChem identifier
54685215 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O -
Source
Synthetic
