IM 54 (2-(1H-Indol-3-yl)-3-pentylamino-maleimide), Necrosis inhibitor (ab145231)
Key features and details
- Potent, selective necrosis inhibitor
- CAS Number: 861891-50-1
- Purity: > 98%
- Soluble in ethanol to 25 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IM 54 (2-(1H-Indol-3-yl)-3-pentylamino-maleimide), Necrosis inhibitor -
Description
Potent, selective necrosis inhibitor -
Alternative names
- 2-(1H-Indol-3-yl)-3-pentylamino-maleimide
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Biological description
Potent, selective necrosis inhibitor (IC50 = 3 μM, H2O2 exposed HeLa cells). Reduces oxidative stress-induced necrosis without effecting anticancer drug-induced apoptosis. Inhibits oxidative stress-induced necrotic cell death in vivo. -
Purity
> 98% -
CAS Number
861891-50-1 -
Chemical structure
Properties
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Chemical name
1-Methyl-3-(1-methylindol-3-yl)-4-(pentylamino)pyrrole-2,5-dione -
Molecular weight
325.40 -
Molecular formula
C19H23N3O2 -
PubChem identifier
16760577 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCCCCNC1=C(C(=O)N(C1=O)C)C2=CN(C3=CC=CC=C32)C -
Source
Synthetic
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Research areas