IKK-16, IkappaB kinase inhibitor (ab216471)
Key features and details
- Potent, selective IκB kinase inhibitor
- CAS Number: 1186195-62-9
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
IKK-16, IkappaB kinase inhibitor -
Description
Potent, selective IκB kinase inhibitor -
Alternative names
- IKK Inhibitor VII
- IKK16
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CAS Number
1186195-62-9 -
Chemical structure
Properties
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Chemical name
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride -
Molecular weight
520.09 -
Molecular formula
C28H29N5OS.HCl -
PubChem identifier
56972179 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
SMILES
C1CCN(C1)C2CCN(CC2)C(=O)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC6=CC=CC=C6S5.Cl -
Source
Synthetic
Images
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Functional Studies - IKK-16, IkappaB kinase inhibitor (ab216471) Carretta et al PLoS One. 2017 Dec 14;12(12):e0189102. doi: 10.1371/journal.pone.0189102. eCollection 2017. Fig 5. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Inhibition of the TAK1-NFkB axis phenocopies FLT3-L deprivation.
A) Percentage of Annexin V-positive CB MLL-AF9 cells after 24 hours incubation with DMSO or AZ-TAK1 inhibitor or IKK VII in different concentrations (technical triplicate ± s.d of 3 independent experiments).