I-BET151, pan-BET family inhibitor (ab230362)
Key features and details
- An isoxazole class pan-BET family inhibitor.
- CAS Number: 1300031-49-5
- Purity: > 98%
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
I-BET151, pan-BET family inhibitor -
Description
An isoxazole class pan-BET family inhibitor. -
Alternative names
- GSK1210151A
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Biological description
I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3 and BRD4 with IC50 values of 0.5, 0.25 and 0.79 µM, respectively. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines.
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Purity
> 98% -
CAS Number
1300031-49-5 -
Chemical structure
Properties
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Chemical name
7-(3,5-Dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one -
Molecular weight
415.50 -
Molecular formula
C23H21N5O3 -
PubChem identifier
52912189 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Handling
Toxic, refer to SDS for further information.
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SMILES
CC(ON=C1C)=C1C2=CC(N=CC(N3)=C4N([C@H](C)C5=CC=CC=N5)C3=O)=C4C=C2OC -
Source
Synthetic
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Research areas
- Cell Biology
- Proteolysis / Ubiquitin
- Proteasome / Ubiquitin
- Ubiquitin E3 Enzymes
- RING Finger E3 Ligase
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Co-activators/co-repressors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism