Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

An isoxazole class pan-BET family inhibitor.
CAS Number: 1300031-49-5
Purity: > 98%
Form / State: Solid
Source: Synthetic

Product name

I-BET151, pan-BET family inhibitor
Description

An isoxazole class pan-BET family inhibitor.
Alternative names
- GSK1210151A
Biological description

I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3 and BRD4 with IC₅₀ values of 0.5, 0.25 and 0.79 µM, respectively. Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G₀/G₁ cell cycle arrest in MLL-fusion cell lines.
Purity

> 98%
CAS Number

1300031-49-5
Chemical structure

Chemical name

7-(3,5-Dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one
Molecular weight

415.50
Molecular formula

C₂₃H₂₁N₅O₃
PubChem identifier

52912189
Storage instructions

Shipped at 4°C. Store at -20°C.
Handling

Toxic, refer to SDS for further information.
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SMILES

CC(ON=C1C)=C1C2=CC(N=CC(N3)=C4N([C@H](C)C5=CC=CC=N5)C3=O)=C4C=C2OC
Source

Synthetic
Research areas

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