Harringtonine, translational protein synthesis inhibitor (ab141941)
Key features and details
- Translational protein synthesis inhibitor
- CAS Number: 26833-85-2
- Purity: > 95%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Cephalotaxus harringtonia
Overview
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Product name
Harringtonine, translational protein synthesis inhibitor -
Description
Translational protein synthesis inhibitor -
Biological description
Natural cephalotaxus alkaloid. Blocks protein synthesis through translation elongation inhibition. Immobilizes ribosomes following translation initiation to reveal footprints of initiation sites in vitro. Antitumor agent. Active in vivo.
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Purity
> 95% -
CAS Number
26833-85-2 -
Chemical structure
Properties
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Chemical name
3-[4-Methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate]cephalotaxine -
Molecular weight
531.60 -
Molecular formula
C28H37NO9 -
PubChem identifier
29927670 -
Storage instructions
Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(C)(CCC(CC(=O)OC)(C(=O)OC1C2C3=CC4=C(C=C3CCN5C2(CCC5)C=C1OC)OCO4)O)O -
Source
Cephalotaxus harringtonia
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Research areas
