H8 dihydrochloride, cGMP and cAMP-dependent kinases inhibitor (ab142309)
Key features and details
- cGMP- and cAMP-dependent kinases inhibitor
- CAS Number: 113276-94-1
- Purity: > 98%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
H8 dihydrochloride, cGMP and cAMP-dependent kinases inhibitor -
Description
cGMP- and cAMP-dependent kinases inhibitor -
Biological description
cGMP- and cAMP-dependent kinases inhibitor. Inhibits the activity of PKG (Ki = 0.48 µM) and PKA (Ki = 1.2 µM). Also inhibits PKC (Ki = 15 µM) and myosin-light chain kinase (MLCK; Ki = 68 µM) activity. -
Purity
> 98% -
CAS Number
113276-94-1 -
Chemical structure
Properties
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Chemical name
N-[2-(Methylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride -
Molecular weight
338.25 -
Molecular formula
C12H15N3O2S.2HCl -
PubChem identifier
150584 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2.Cl.Cl -
Source
Synthetic
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Research areas
