GW 6471, PPAR alpha antagonist (ab254317)
Key features and details
- PPAR alpha antagonist
- CAS Number: 880635-03-0
- Purity: > 98%
Soluble in DMSO to 50 mM and ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GW 6471, PPAR alpha antagonist -
Description
PPAR alpha antagonist -
Biological description
Potent PPAR alpha antagonist (IC50 = 240 nM). Drives displacement of co-activators from PPAR alpha. Promotes recruitment of co-repressor proteins SMRT and NCoR to ligand binding domain. Inhibits cardiomyocyte differentiation in mouse embryonic stem cells. Causes reduced expression of cardiac sarcomeric proteins and specific genes in a time-dependent manner.
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Purity
> 98% -
General notes
Protect from air and light.
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CAS Number
880635-03-0 -
Chemical structure
Properties
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Chemical name
N-[(2S)-3-[4-[2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]-2-[[(Z)-4-oxo-4-[4-(trifluoromethyl)phenyl]but-2-en-2-yl]amino]propyl]propanamide
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Molecular weight
619.68 -
Molecular formula
C35H36F3N3O4 -
PubChem identifier
446738 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
Soluble in DMSO to 50 mM and ethanol to 10 mM
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Handling
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCC(=O)NC[C@H](CC1=CC=C(C=C1)OCCC2=C(OC(=N2)C3=CC=CC=C3)C)N/C(=C\C(=O)C4=CC=C(C=C4)C(F)(F)F)/C -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
