GSK429286A, ROCK1 and ROCK2 inhibitor (ab146581)
Key features and details
- Selective ROCK1 and ROCK2 inhibitor
- CAS Number: 864082-47-3
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK429286A, ROCK1 and ROCK2 inhibitor -
Description
Selective ROCK1 and ROCK2 inhibitor -
Biological description
Selective ROCK1 and ROCK2 inhibitor. Demonstrated inhibition of ROCKs at 140 nM. Reduces ROCK2 activity over 20-fold at 1 μM. Active in vitro. -
Purity
> 98% -
CAS Number
864082-47-3 -
Chemical structure
Properties
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Chemical name
4-[4-(Trifluoromethyl)phenyl]-N-(6-fluoro-1H-indazol-5-yl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxamide -
Molecular weight
432.37 -
Molecular formula
C21H16F4N4O2 -
PubChem identifier
11373846 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F -
Source
Synthetic
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Research areas
