GSK-106 hydrochloride, negative control for GSK-121 and GSK-484 (ab229184)
Key features and details
- Useful negative control for PAD4 inhibitors GSK-121 and GSK-484.
- CAS Number: 1652591-82-6
- Purity: > 98%
- Soluble in DMSO to 65 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GSK-106 hydrochloride, negative control for GSK-121 and GSK-484 -
Description
Useful negative control for PAD4 inhibitors GSK-121 and GSK-484. -
Alternative names
- (3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride
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Biological description
Useful negative control for PAD4 inhibitors GSK-121 and GSK-484. Does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC50s > 100 µM).
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Purity
> 98% -
CAS Number
1652591-82-6
Properties
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Chemical name
(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride -
Molecular weight
437.97 -
Molecular formula
C24H27N5O.HCl -
Storage instructions
Shipped at 4°C. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 65 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(N1CC(N)CCC1)C2=CC=C3C(N(C)C(C(N4CC)=CC5=C4C=CC=C5)=N3)=C2.[H]Cl -
Source
Synthetic
