GR 125743, 5-HT1B/1D antagonist (ab120349)
Key features and details
- 5-HT1B/1D antagonist
- CAS Number: 148547-33-5
- Purity: > 99%
- Soluble in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
GR 125743, 5-HT1B/1D antagonist -
Description
5-HT1B/1D antagonist -
Biological description
5-HT1B / 1D antagonist (pKi = 8.5), often used in tritiated form as a radiolabelled probe. Shows approx. 100-fold selectivity over other 5-HT receptors and shows CNS and oral activity.
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Purity
> 99% -
CAS Number
148547-33-5 -
Chemical structure
Properties
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Chemical name
N-[4-Methoxy-3-(4-methylpiperazin-1-yl)phenyl]-3-methyl-4-(pyridin-4-yl)benzamide -
Molecular weight
416.52 -
Molecular formula
C25H28N4O2 -
PubChem identifier
5311130 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN1CCN(CC1)c4cc(NC(=O)c3ccc(c2ccncc2)c(C)c3)ccc4OC -
Source
Synthetic
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Research areas
