Givinostat hydrochloride (ab254241)
Key features and details
- Potent hydroxamate-based Class I and Class II HDAC inhibitor.
- CAS Number: 732302-99-7
- Purity: > 98%
DMSO: 45 mg/mL
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Givinostat hydrochloride -
Description
Potent hydroxamate-based Class I and Class II HDAC inhibitor. -
Alternative names
- ITF2357
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Biological description
Potent hydroxamate-based inhibitor of Class I and Class HDACs (IC50 = 7.5 - 16 nM). Reduces the release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Has anti-tumor activity in a number of cancer cell lines.
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Purity
> 98% -
General notes
Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. Protect from air and moisture.
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CAS Number
732302-99-7 -
Chemical structure
Properties
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Chemical name
[6-(Diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate hydrate hydrochloride
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Molecular weight
475.97 -
Molecular formula
C24H27N3O4.H2O.HCl -
PubChem identifier
9804991 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. -
Solubility overview
DMSO: 45 mg/mL
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Handling
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCN(CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.Cl -
Source
Synthetic
