Garcinol, HAT p300 and PCAF inhibitor (ab141503)
Key features and details
- Potent HAT p300 and PCAF inhibitor. Pleiotropic agent.
- CAS Number: 78824-30-3
- Purity: > 95%
- Soluble in DMSO to 25 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Garcinol, HAT p300 and PCAF inhibitor -
Description
Potent HAT p300 and PCAF inhibitor. Pleiotropic agent. -
Biological description
Potent histone acetyltransferase p300 and PCAF inhibitor (IC50 values are 7 and 5 μM for p300 and PCAF respectively). Pleiotropic agent. Strongly inhibits chromatin transcription and induces apoptosis. Inhibits histone acetylation in vivo. Antioxidant and chemoprotective agent. -
Purity
> 95% -
CAS Number
78824-30-3 -
Chemical structure
Properties
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Chemical name
3-[(3,4-Dihydroxyphenyl)-hydroxymethylidene]-6,6-dimethyl-5,7-bis(3-methylbut-2-enyl)-1-(5-methyl-2-prop-1-en-2-ylhex-4-enyl)bicyclo[3.3.1]nonane-2,4,9-trione -
Molecular weight
602.80 -
Molecular formula
C38H50O6 -
PubChem identifier
3531 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C -
Source
Synthetic
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Research areas
