FPS-ZM1, RAGE receptor antagonist (ab235552)
Key features and details
- High-affinity RAGE receptor antagonist
- CAS Number: 945714-67-0
- Purity: > 98%
Soluble in DMSO to 198.26 mM and in ethanol to 198.26 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
FPS-ZM1, RAGE receptor antagonist -
Description
High-affinity RAGE receptor antagonist -
Biological description
High-affinity, blood-brain-barrier permeable, non-toxic, tertiary amide RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). Blocks Aβ binding to the V domain of RAGE. Inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo.
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Purity
> 98% -
CAS Number
945714-67-0 -
Chemical structure
Properties
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Chemical name
4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide
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Molecular weight
327.85 -
Molecular formula
C20H22ClNO -
PubChem identifier
24752728 -
Storage instructions
Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 198.26 mM and in ethanol to 198.26 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CCC(CC1)N(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)Cl -
Source
Synthetic
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Research areas