Flunarizine dihydrochloride, dual Na+/Ca2+ channel blocker (ab141798)
Key features and details
- Potent dual Na+/Ca2+ channel blocker
- CAS Number: 30484-77-6
- Purity: > 99%
- Soluble in ethanol to 5 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Flunarizine dihydrochloride, dual Na+/Ca2+ channel blocker -
Description
Potent dual Na+/Ca2+ channel blocker -
Biological description
Potent dual Na+/Ca2+ channel blocker (IC50 values are 0.4 and 2.2 μM for Na+ and voltage-gated T-type Ca2+ channels respectively). Shows vasodilatory and neuroprotective effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
30484-77-6 -
Chemical structure
Properties
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Chemical name
1-[Bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine dihydrochloride -
Molecular weight
477.40 -
Molecular formula
C26H26F2N2.2HCl -
PubChem identifier
5282407 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 5 mM and in DMSO to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl -
Source
Synthetic
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Research areas
Images
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Functional Studies - Flunarizine dihydrochloride, dual Na+/Ca2+ channel blocker (ab141798)Flunarizine dihydrochloride blocks L-type Ca2+ currents in Xenopus oocytes.
A. Time course of L-type channel (CaV1.2+a2d1+ß1a) activity before and during applications of 10 and 100 µM Flunarizine dihydrochloride (ab141798) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV. Periods of compound application are indicated by the horizontal bars. B. Example of superimposed current traces before and during application of 10 and 100 µM Flunarizine dihydrochloride (taken from the experiment described in A).
