Flumazenil, Benzodiazepine antagonist (ab120242)
Key features and details
- Benzodiazepine antagonist
- CAS Number: 78755-81-4
- Purity: > 99%
- Soluble in DMSO to 25 mM (with warming) and in ethanol to 5 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Flumazenil, Benzodiazepine antagonist -
Description
Benzodiazepine antagonist -
Alternative names
- Ro 15-1788
-
Biological description
Selective non-competitive benzodiazepine antagonist with low affinity for α4- and α6-subunits
-
Purity
> 99% -
CAS Number
78755-81-4 -
Chemical structure
Properties
-
Chemical name
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1 ,4]benzodiazepine-3-carboxylic acid ethyl ester -
Molecular weight
303.29 -
Molecular formula
C15H14FN3O3 -
PubChem identifier
3373 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM (with warming) and in ethanol to 5 mM (with heating) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
O=C(OCC)c3ncn2c3CN(C)C(=O)c1cc(F)ccc12 -
Source
Synthetic
-
Research areas
- Biochemicals
- Pharmacology
- Receptors & Transporters
- GABA
- GABAA
- Benzodiazepine Site
- Antagonists / inverse agonists
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipases
- Biochemicals
- Research Area
- Pain & inflammation
- GABA
- GABAA
- Benzodiazepine Site
- Antagonists / inverse agonists
Images
-
Functional Studies - Flumazenil, Benzodiazepine antagonist (ab120242) Jin et al PLoS One. 2011; 6(1): e16188. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/
Inhibition of insulin (1 nM) induced tonic current by flumazenil and zolpidem.
Effects of flumazenil (1 µM) on the currents in an ACSF (a) and an insulin treated neuron (b).
(From Figure 2A of Jin et al).