Fludarabine (FAMP), DNA synthesis inhibitor (ab141048)
Key features and details
- DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A.
- CAS Number: 21679-14-1
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Fludarabine (FAMP), DNA synthesis inhibitor -
Description
DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A. -
Biological description
DNA synthesis inhibitor. Prodrug converted to active metabolite F-ara-A which inhibits ribonucleotide reductase and competitively inhibits DNA polymerase. Also prevents DNA ligase I from joining DNA. Induces apoptosis. Active in vivo.
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Purity
> 98% -
CAS Number
21679-14-1 -
Chemical structure
Properties
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Chemical name
9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine -
Molecular weight
285.23 -
Molecular formula
C10H12FN5O4 -
PubChem identifier
8975 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Nc3nc(F)nc2c3ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
