Etomidate, GABAA agonist (ab120311)
Key features and details
- GABAA agonist
- CAS Number: 33125-97-2
- Purity: > 98%
- Soluble in DMSO to 100 mM, in ethanol to 500 mM, in 1 eq. HCl to 100 mM (with heating) and in water to 1 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Etomidate, GABAA agonist -
Description
GABAA agonist -
Biological description
Agonist at GABAA receptors containing β3 subunits. Anaesthetic and amnesic properties.
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Purity
> 98% -
CAS Number
33125-97-2 -
Chemical structure
Properties
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Chemical name
Ethyl 1-((R)-1-phenylethyl)-1H-imidazole-5-carboxylate -
Molecular weight
244.29 -
Molecular formula
C14H16N2O2 -
PubChem identifier
667484 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM, in ethanol to 500 mM, in 1 eq. HCl to 100 mM (with heating) and in water to 1 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@H](c1ccccc1)n2cncc2C(=O)OCC -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
Images
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Functional Studies - Etomidate, GABAA agonist (ab120311)ab7977 staining BAX in RAW 264.7 cells treated with etomidate (ab120311), by ICC/IF. Increase in BAX expression correlates with increased concentration of etomidate, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120311 (etomidate) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab7977 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
