EMD 386088 hydrochloride, 5-HT6 agonist (ab120328)
Key features and details
- Potent 5-HT6 agonist
- CAS Number: 54635-62-0
- Purity: > 98%
- Soluble in water to 25 mM (with heating) and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
EMD 386088 hydrochloride, 5-HT6 agonist -
Description
Potent 5-HT6 agonist -
Biological description
Potent 5-HT6 agonist (IC50 = 7.4 nM in 3H-LSD binding and EC50 = 1.0 nM in a functional cAMP assay). Selective over other 5-HT receptors (IC50 values are 110 (5-HT1D), 180 (5-HT1B), 240 (5-HT2A), 450 (5-HT2C), 620 (5-HT4), 660 (5-HT1A ) and 3000 nM (5-HT7)). Shows moderate affinity at 5-HT3 receptors (IC50 = 34 nM). Impairs memory in vivo.
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Purity
> 98% -
CAS Number
54635-62-0 -
Chemical structure
Properties
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Chemical name
5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-Indole hydrochloride -
Molecular weight
283.20 -
Molecular formula
C14H15N2.HCl -
PubChem identifier
56972198 -
Storage instructions
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 25 mM (with heating) and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Clc2ccc3nc(C)c(C1=CCNCC1)c3c2 -
Source
Synthetic
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Research areas
