Dovitinib, class III-V receptor tyrosine kinase inhibitor (ab216312)
Key features and details
- Potent, selective class III-V receptor tyrosine kinase inhibitor
- CAS Number: 405169-16-6
- Purity: > 99%
Soluble in DMSO (up to 30 mg/ml)
- Form / State: Solid
- Source: TLC and HPLC
Overview
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Product name
Dovitinib, class III-V receptor tyrosine kinase inhibitor -
Description
Potent, selective class III-V receptor tyrosine kinase inhibitor -
Alternative names
- CHIR258
- TKI-258
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Biological description
Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
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Purity
> 99% -
CAS Number
405169-16-6 -
Chemical structure
Properties
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Chemical name
4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one -
Molecular weight
392.43 -
Molecular formula
C21H21FN6O -
PubChem identifier
9886808 -
Storage instructions
Shipped at Room Temperature. Store at -20°C long term. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO (up to 30 mg/ml)
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SMILES
CN1CCN(CC1)c2cc3nc(nc3cc2)C4=C(N)c5c(F)cccc5NC4=O -
Source
TLC and HPLC
