Dorsomorphin dihydrochloride, AMP-kinase inhibitor (ab144821)
Key features and details
- Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor.
- CAS Number: 1219168-18-9
- Purity: > 99%
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dorsomorphin dihydrochloride, AMP-kinase inhibitor -
Description
Potent, selective, reversible AMP-kinase inhibitor. BMP type I receptor inhibitor. -
Biological description
Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo.
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Purity
> 99% -
CAS Number
1219168-18-9 -
Chemical structure
Properties
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Chemical name
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine dihydrochloride -
Molecular weight
472.42 -
Molecular formula
C24H25N5O.2HCl -
PubChem identifier
49761481 -
Storage instructions
Store at -20°C (desiccating conditions). -
Solubility overview
Soluble in water to 100 mM -
Handling
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SMILES
C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl -
Source
Synthetic
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Research areas
