Doramapimod, p38 MAPK inhibitor (ab142166)
Key features and details
- Potent, selective, cell permeable p38 MAPK inhibitor
- CAS Number: 285983-48-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Doramapimod, p38 MAPK inhibitor -
Description
Potent, selective, cell permeable p38 MAPK inhibitor -
Alternative names
- BIRB 796
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Biological description
Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.
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Purity
> 98% -
CAS Number
285983-48-4 -
Chemical structure
Properties
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Chemical name
1-[5-tert-Butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4- ylethoxy)naphthalen-1-yl]urea -
Molecular weight
527.66 -
Molecular formula
C31H37N5O3 -
PubChem identifier
156422 -
Storage instructions
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5 -
Source
Synthetic
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Research areas