Antibodies, Proteins, Kits and Reagents for Life Science

Key features and details

Potent HIV integrase inhibitor
CAS Number: 1051375-16-6
Soluble in DMSO to 5mM.
Form / State: Solid
Source: Synthetic

Product name

Dolutegravir, HIV integrase inhibitor
Description

Potent HIV integrase inhibitor
Alternative names
- DTG
- GSK1349572
- S/GSK1349572
Biological description

Potent HIV integrase inhibitor (IC₅₀ = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro). Inhibits HIV-1 viral replication (EC₅₀ = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). Prevents replication of several HIV-1 strains (EC₅₀ values of 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors.
CAS Number

1051375-16-6
Chemical structure

Chemical name

(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-7-hydroxy-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide
Molecular weight

419.39
Molecular formula

C₂₀H₁₉F₂N₃O₅
PubChem identifier

54726191
Storage instructions

Shipped at 4°C. Store at -20°C.
Solubility overview

Soluble in DMSO to 5mM.
SMILES

C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O
Source

Synthetic
Research areas

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