Dolutegravir, HIV integrase inhibitor (ab231511)
Key features and details
- Potent HIV integrase inhibitor
- CAS Number: 1051375-16-6
Soluble in DMSO to 5mM.
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Dolutegravir, HIV integrase inhibitor -
Description
Potent HIV integrase inhibitor -
Alternative names
- DTG
- GSK1349572
- S/GSK1349572
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Biological description
Potent HIV integrase inhibitor (IC50 = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro). Inhibits HIV-1 viral replication (EC50 = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). Prevents replication of several HIV-1 strains (EC50 values of 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors.
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CAS Number
1051375-16-6 -
Chemical structure
Properties
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Chemical name
(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-7-hydroxy-4-methyl-6,8-dioxo-3,4,12,12a-tetrahydro-2H-pyrido[5,6]pyrazino[2,6-b][1,3]oxazine-9-carboxamide
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Molecular weight
419.39 -
Molecular formula
C20H19F2N3O5 -
PubChem identifier
54726191 -
Storage instructions
Shipped at 4°C. Store at -20°C. -
Solubility overview
Soluble in DMSO to 5mM.
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SMILES
C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)O -
Source
Synthetic
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Research areas