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Dimethylamiloride hydrochloride (5-(N,N-Dimethyl)amiloride hydrochloride), Na+/H+ exchange blocker (ab145569)

Price and availability

335 040 ₸

Availability

Order now and get it on Friday March 05, 2021

Key features and details

  • Selective Na+/H+ exchange blocker
  • CAS Number: 2235-97-4
  • Purity: > 97%
  • Soluble in DMSO to 10 mM
  • Form / State: Solid
  • Source: Synthetic

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Overview

  • Product name

    Dimethylamiloride hydrochloride (5-(N,N-Dimethyl)amiloride hydrochloride), Na+/H+ exchange blocker
  • Description

    Selective Na+/H+ exchange blocker
  • Alternative names

    • 5-(N,N-Dimethyl)amiloride hydrochloride
  • Biological description

    Selective Na+/H+ exchange blocker (IC50 = 6.9 μM). Shows greater potency and selectivity than analog, amiloride (ab145993, ab120281). Inhibits proliferation and induces differentiation of HL-60 cells. Shows anti-ischemic effects in vivo.

  • Purity

    > 97%
  • CAS Number

    2235-97-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Amino-N-(aminoiminomethyl)-6-chloro-5-(dimethylamino)-2-pyrazinecarboxamide hydrochloride
  • Molecular weight

    294.14
  • Molecular formula

    C8H12ClN7O.HCl
  • PubChem identifier

    11957442
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N.Cl
  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • DNA / RNA
    • DNA Damage & Repair
    • Homologous Recomb.
    • Biochemicals
    • Product Range
    • New
    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Transporters
    • Ion pumps / transporter
    • Na+/H+ exchanger

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

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