Cytochalasin B, actin polymerization inhibitor (ab143482)
Key features and details
- Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker.
- CAS Number: 14930-96-2
- Purity: > 97%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Drechslera dematoidea
Overview
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Product name
Cytochalasin B, actin polymerization inhibitor -
Description
Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker. -
Biological description
Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker (IC50 = 4 μM). Inhibits I(Kur). Cytochalasin A (ab143481) analog. Inhibits transport of monosaccharides across the cell membrane. Shows antitumor effects in vivo. -
Purity
> 97% -
CAS Number
14930-96-2 -
Chemical structure
Properties
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Chemical name
(3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-6,7,8,9,10,12a,13,14,15,15a,16,17-Dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione -
Molecular weight
479.61 -
Molecular formula
C29H37NO5 -
PubChem identifier
5311281 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C[C@@H]1CCC[C@@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)Cc4ccccc4)C)O)O -
Source
Drechslera dematoidea
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Research areas
