Crenolanib (CP-868596) (ab273385)
Key features and details
- Potent PDGFR and FLT3 inhibitor
- CAS Number: 670220-88-9
- Purity: = 97%
Soluble in DMSO to 25 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Crenolanib (CP-868596) -
Description
Potent PDGFR and FLT3 inhibitor -
Biological description
Potent inhibitor of PDGFR (Kd for alpha = 2.1 nM; beta = 3.2 nM) and FLT3 (Kd = 0.74 nM). Type I inhibitor that binds only the active kinase conformation. Active towards imatinib-resistance assciated PDGFR-alpha mutations (D842I, D842V, D842Y, DI842-843M, and deletion I843). Active against FLT3/ITD and FLY3/D835 mutatants. Over 100-fold selective for PDGFR versus c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
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Purity
= 97% -
CAS Number
670220-88-9 -
Chemical structure
Properties
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Chemical name
1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine
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Molecular weight
443.54 -
Molecular formula
C26H29N5O2 -
PubChem identifier
10366136 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 25 mM and in ethanol to 10 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4 -
Source
Synthetic
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Research areas
Images
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Chemical Structure - Crenolanib (CP-868596) (ab273385)
Chemical structure of Crenolanib (CP-868596), 670220-88-9