CPI-169, EZH2 inhibitor (ab269818)
Key features and details
- Potent inhibitor of EZH2
- CAS Number: 1450655-76-1
Soluble in DMSO to 50 mM
- Form / State: Solid
Overview
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Product name
CPI-169, EZH2 inhibitor -
Description
Potent inhibitor of EZH2 -
Biological description
Potent EZH2 inhibitor (IC50 = 0.24 nM). Selective versus EZH1 (IC50 = 6.1 nM). In KARPAS-422 cells, CPI-169 shows a dose-dependent inhibitory effect on cell viability, and produces synergy anti-proliferative activity when used in combination with ABT-199. In 16 out of 25 NHL cell lines, CPI-169 also suppresses cell growth with GI50 of
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CAS Number
1450655-76-1 -
Chemical structure
Properties
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Chemical name
N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3- pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3- pyridinyl]-1H-indole-4-carboxamide -
Molecular weight
528.66 -
Molecular formula
C27H36N4O5S -
PubChem identifier
78357814 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 50 mM
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Handling
Toxic, refer to SDS for further information.
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SMILES
CCS(=O)(=O)N1CCC(CC1)C(C)N2C(=C(C3=CC=CC=C32)C(=O)NCC4=C(C=C(NC4=O)C)OC)C
Images
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Chemical Structure - CPI-169, EZH2 inhibitor (ab269818)
Chemical structure of CPI-169, EZH2 inhibitor, 1450655-76-1