Coumestrol, anti-estrogenic agent (ab143477)
Key features and details
- Potent atypical anti-estrogenic agent.17-β−hydroxysteroid oxidoreductase inhibitor
- CAS Number: 479-13-0
- Purity: > 97%
- Soluble in ethanol
- Form / State: Solid
Overview
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Product name
Coumestrol, anti-estrogenic agent -
Description
Potent atypical anti-estrogenic agent.17-β−hydroxysteroid oxidoreductase inhibitor -
Biological description
Potent atypical anti-estrogenic agent. 17-β−hydroxysteroid oxidoreductase inhibitor. Competitively binds with higher affinity to ERβ than ERα. Inhibits transcriptional activity of both ER subtypes (IC50 = 1-10 nM). Activates Sirt1. Induces mitochondrial biogenesis. Shows antioxidant and neuroprotective effects in vivo. Orally active. -
Purity
> 97% -
CAS Number
479-13-0 -
Chemical structure
Properties
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Chemical name
3,9-Dihydroxy-[1]benzofuro[3,2-c]chromen-6-one -
Molecular weight
268.20 -
Molecular formula
C15H8O5 -
PubChem identifier
5281707 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC2=C(C=C1O)OC3=C2C(=O)OC4=C3C=CC(=C4)O -
Research areas