Compound 6877002, CD40-TRAF6 interaction inhibitor (ab146829)
Key features and details
- CD40-TRAF6 interaction inhibitor
- CAS Number: 433249-94-6
- Purity: > 99%
- Soluble in ethanol to 100 mM and in DMSO to 100mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Compound 6877002, CD40-TRAF6 interaction inhibitor -
Description
CD40-TRAF6 interaction inhibitor -
Alternative names
- 3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one
- 6877002
- CD40-TRAF6 signaling inhibitor
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Biological description
CD40-TRAF6 interaction inhibitor. Small molecule that binds to TRAF6, blocking interactions with CD40. Suppresses CD40-induced IL-1β and IL-6 expression in primary macrophages in vitro. Improves insulin sensitivity, reduces adipose tissue inflammation, and ameliorates hepatosteatosis in a mouse diet-induced obesity model.
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Purity
> 99% -
CAS Number
433249-94-6 -
Chemical structure
Properties
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Chemical name
3-[(2,5-Dimethylphenyl)amino]-1-phenyl-2-propen-1-one -
Molecular weight
251.33 -
Molecular formula
C17H17NO -
Storage instructions
Shipped at 4°C. Store at +4°C. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cc2cc(N/C=C/C(=O)c1ccccc1)c(C)cc2 -
Source
Synthetic
