Clofarabine, Purine analogue (ab142732)
Key features and details
- Antimetabolite agent. Purine analogue.
- CAS Number: 123318-82-1
- Purity: > 98%
- Soluble in water to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
Clofarabine, Purine analogue -
Description
Antimetabolite agent. Purine analogue. -
Biological description
Antimetabolite agent. Purine analogue. Deoxycytidine kinase substrate. Competes with dATP for DNA polymerase-α and -ε. Potent ribonucleotide reductase inhibitor (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Shows antitumor effects in vivo. -
Purity
> 98% -
CAS Number
123318-82-1 -
Chemical structure
Properties
-
Chemical name
(2R,3R,4S,5R)-5-(6-Amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol -
Molecular weight
303.68 -
Molecular formula
C10H11ClFN5O3 -
PubChem identifier
119182 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 10 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1=NC2=C(N1C3C(C(C(O3)CO)O)F)N=C(N=C2N)Cl -
Source
Synthetic
-
Research areas