clasto-Lactacystin beta-lactone, 20S proteasome inhibitor (ab141412)
Key features and details
- Potent, irreversible and cell-permeable 20S proteasome inhibitor
- CAS Number: 154226-60-5
- Purity: > 95%
- Soluble in DMSO to 75 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
clasto-Lactacystin beta-lactone, 20S proteasome inhibitor -
Description
Potent, irreversible and cell-permeable 20S proteasome inhibitor -
Biological description
Potent, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 50 nM). Active metabolite of lactacystin (ab141411). Inhibits cell-cycle progression in cancer cells. Antitumor agent. Active in vivo and in vitro. -
Purity
> 95% -
CAS Number
154226-60-5 -
Chemical structure
Properties
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Chemical name
(1S,2R,5R)-5-[(1S)-1-Hydroxy-2-methylpropyl]-2-methyl-7-oxa-4-azabicyclo[3.2.0]heptane-3,6-dione -
Molecular weight
213.23 -
Molecular formula
C10H15NO4 -
PubChem identifier
9794358 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 75 mM and in water to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC1C2C(C(=O)O2)(NC1=O)C(C(C)C)O -
Source
Synthetic
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Research areas