Cisapride, 5-HT4 receptor agonist (ab120548)
Key features and details
- 5-HT4 receptor agonist. hERG blocker.
- CAS Number: 81098-60-4
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Cisapride, 5-HT4 receptor agonist -
Description
5-HT4 receptor agonist. hERG blocker. -
Biological description
5-HT4 receptor agonist (EC50 = 140 nM). Potent human ether-a-go-go-related gene (hERG) channel blocker (IC50 = 9.4 nM). Gastrokinetic agent, increases intestinal motility.
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Purity
> 99% -
CAS Number
81098-60-4 -
Chemical structure
Properties
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Chemical name
(±)-4-Amino-5-chloro-N-[1-[(3R*,4S*)-3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide -
Molecular weight
465.95 -
Molecular formula
C23H29ClFN3O4 -
PubChem identifier
6917698 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM (with warming) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Clc1cc(c(OC)cc1N)C(=O)N[C@@H]3CCN(CCCOc2ccc(F)cc2)C[C@@H]3OC -
Source
Synthetic
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Research areas