CHIR 98014, ATP-competitive GSK3 inhibitor (ab146582)
Key features and details
- Potent, selective ATP-competitive GSK3 inhibitor
- CAS Number: 556813-39-9
- Purity: > 98%
- Soluble in DMSO to 5 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CHIR 98014, ATP-competitive GSK3 inhibitor -
Description
Potent, selective ATP-competitive GSK3 inhibitor -
Biological description
Potent, selective ATP-competitive GSK3 inhibitor (IC50 values are 0.58 and 0.65 nM for GSKα and GSKβ respectively). Potently activates the Wnt/beta-catenin signaling pathway. Also supplied as solution (ab146633). -
Purity
> 98% -
CAS Number
556813-39-9 -
Chemical structure
Properties
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Chemical name
N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-pyridinediamine -
Molecular weight
486.32 -
Molecular formula
C20H17Cl2N9O2 -
PubChem identifier
53396311 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 5 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N -
Source
Synthetic
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Research areas
