CHIR-124 (ab273615)
Key features and details
- Novel and potent Chk1 inhibitor
- CAS Number: 405168-58-3
- Purity: > 98%
Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
-
Product name
CHIR-124 -
Description
Novel and potent Chk1 inhibitor -
Biological description
Novel and potent Chk1 inhibitor (IC50 = 0.3 nM), 2,000-fold more potent than Chk2 (IC50 = 0.7 μM). Also, potently targets other kinases such as FLT3 (IC50 = 5.8 nM), PDGFR (IC50 = 6.6 nM), GSK-3 (IC50 = 23.3 nM) and Fyn (IC50 = 98.8 nM) .
-
Purity
> 98% -
General notes
For obtaining a higher solubility, please warm the tube at 37°C and shake in the ultrasonic bath for a while.
-
CAS Number
405168-58-3 -
Chemical structure
Properties
-
Chemical name
4-[(3S)-1-Azabicyclo[2.2.2]oct-3-ylamino]-3-(1H-benzimidazol-2-yl)-6- chloro-2(1H)-quinolinone
-
Molecular weight
419.91 -
Molecular formula
C23H22ClN5O -
PubChem identifier
135399748 -
Storage instructions
Shipped at room temperature. Store at -20°C. -
Solubility overview
Soluble in DMSO to 25 mM
-
Handling
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
-
SMILES
C1CN2CCC1[C@@H](C2)NC3=C(C(=O)NC4=C3C=C(C=C4)Cl)C5=NC6=CC=CC=C6N5 -
Source
Synthetic
Images
-
Chemical Structure - CHIR-124 (ab273615)
Chemical structure of CHIR-124, 405168-58-3