CDPPB, positive allosteric modulator for mGlu5 (ab120363)
Key features and details
- PAM for mGlu5. Active in vivo.
- CAS Number: 781652-57-1
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CDPPB, positive allosteric modulator for mGlu5 -
Description
PAM for mGlu5. Active in vivo. -
Biological description
Potent, selective, positive allosteric modulator for mGlu5. In CHO cells expressing mGlu5 receptors, potentiates threshold responses to glutamate in fluorometric Ca2+ assays more than 7-fold (EC50 approximately 27 nM). Acts as mGlu5 agonist at higher concentrations. Brain penetrant and antipsychotic in vivo.
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Purity
> 98% -
CAS Number
781652-57-1 -
Chemical structure
Properties
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Chemical name
3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide -
Molecular weight
364.41 -
Molecular formula
C23H16N4O -
PubChem identifier
11245456 -
Storage instructions
Store at +4°C. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
N#Cc1cccc(c1)C(=O)Nc3cc(nn3c2ccccc2)c4ccccc4 -
Source
Synthetic
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Research areas
