CAY10585, HIF-1alpha inhibitor (ab144422)
Key features and details
- HIF-1α inhibitor
- CAS Number: 934593-90-5
- Purity: > 97%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CAY10585, HIF-1alpha inhibitor -
Description
HIF-1α inhibitor -
Biological description
HIF-1α inhibitor (IC50 values are 2.6 and 0.7 µM for Hep3B and AGS cell lines respectively). Suppresses transcription of HIF-1 target genes VEGF and erythropoietin at 10 µM. Attenuates hypoxia-induced ANP secretion. Blunts BMP9-induced osteogenic signaling in MSCs. -
Purity
> 97% -
CAS Number
934593-90-5 -
Chemical structure
Properties
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Chemical name
Methyl 3-[[2-[4-(2-adamantyl)phenoxy]acetyl]amino]-4-hydroxybenzoate -
Molecular weight
435.52 -
Molecular formula
C26H29NO5 -
PubChem identifier
35028748 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C3C4CC5CC(C4)CC3C5 -
Source
Synthetic
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Research areas