CAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor (ab144419)
Key features and details
- Potent dual Cdc7 and Cdk9 kinase inhibitor
- CAS Number: 845714-00-3
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
CAY10572 (PHA-767491), Cdc7 and Cdk9 kinase inhibitor -
Description
Potent dual Cdc7 and Cdk9 kinase inhibitor -
Alternative names
- PHA-767491
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Biological description
Potent Cdc7 and Cdk9 kinase inhibitor (IC50 values are 10 and 34 nM for Cdc7 in the presence of 1.5 µM ATP and Cdk9 respectively). Induces apoptosis in cancer cell lines. Shows synergistic antitumor effects in vivo with 5-fluorouracil (ab142387). -
Purity
> 98% -
CAS Number
845714-00-3 -
Chemical structure
Properties
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Chemical name
2-Pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one -
Molecular weight
213.24 -
Molecular formula
C12H11N3O -
PubChem identifier
11715767 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3 -
Source
Synthetic
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Research areas
